63  Thiazide Diuretics

	HCTZ	Chlorthalidone	Indapamide	Comments
Half life (h)	3-10	24-55	6-15
Duration of action (h)	12-18	24-72	24-36
Usual dosage (mg)	12.5-50	12.5-25	1.25-2.5
Antihypertensive effect	Weak	Strong	Intermediate	Chlorthalidone is twice as potent as HCTZ.
Pleiotropic effects	No	Yes	Yes	Unlike HCTZ, Chlorthalidone and Indapamide are renoprotective, block carbonic anhydrase isoenzymes, promote angiogenesis, and ↓ vascular permeability and plt aggregation.

63.1 Chlorthalidone

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  • Chlorthalidone for HTN in advanced CKD (Agarwal et al. 2021)

Agarwal, Rajiv, Arjun D. Sinha, Andrew E. Cramer, Mary Balmes-Fenwick, Jazmyn H. Dickinson, Fangqian Ouyang, and Wanzhu Tu. 2021. “Chlorthalidone for Hypertension in Advanced Chronic Kidney Disease.” New England Journal of Medicine 385 (27): 2507–19. https://doi.org/10.1056/nejmoa2110730.