Furosemide can probably be given to patients with sulfa allergies, but there is risk for cross-reactivity (~10%)
There is no standard way to taper clonidine and no consensus has been reached on length of taper
Eye drops can be absorbed systemically and are often used without proper instructions
Systemic absorption occurs when fluid drains into the vascular nasal mucosa via the lacrimal duct (a process promoted by blinking). Mitigate this by telling patients to close their eyes for 2-3 minutes after administration
Beta-blockade prevents nitroprusside-induced reflex tachycardia, thereby decreasing shear stress on the aorta
CKD is not a contraindication to use of nitroprusside (cyanide toxicity does not occur until at least 24 to 48 hours after initiation of the medication)